Dr. Ben Danielson discusses treatment options for children with sickle cell anemia.

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are there any differences in availibility of treatment for sickle cell anameia in developed and underdeveloped countries??

i would have thought that there would be because most treatment has been discovered and developed in more developed countries and because there richer countries have more money, they have greater access to the (limited) resources. and it may have something to do with creating a division between the rich and poor.

but i can’t find anything on the internet to give any more information.. can anyone perhaps direct me to suitable websites they can find ??

thanks

The quality of treatment would vary between developing and developed countries … to put it simply a person in "sickle cell crisis" tends to be in immense pain and depending on how severe the crisis is they may need ICU treatment or at least hospitalisation…and there is a mayor difference between standards of care in developed countries compared to underdeveloped countries. I would even go so far as to say there is a diffence in care between a rural hospital and a metropolitin hospital…there is far more resources in large teaching hospital compared to the small country town clinic. You also have to keep in mind that only a small amount of the population has sickle cell anameia so a rural hospital is not likely to see anyone with that disease for years so when the unlucky person who has sickle cell anameia happens to walk into that emergency department in a sickle cell crisis the likelyhood of the staff knowing what to do is small. whereas large metropolitin hospitals would see at least a few sickle cell crisis a year so have more experience in the care of that person.

Also developed countries have the resources to test babies at birth for sickle cell anameia and the sooner it is discovered the better the management and outcome is…

In developed countries children with sickle cell anemia are seen on a regular basis in outpatient clinics attached to hospitals so that they are monitored and treated before they ended up in total crisis, you wouldn’t get these clinics in developing countries, the money isn’t there for them.

In developing countries the discovery the child has sickle cell anemia would only occur once the child presented in a sickle cell crisis.

Video walkthrough of the “Rescue Commissioner Gordon” objective (PT. 1) in Batman: Arkham Asylum on Xbox 360. This video shows Riddler trophy #5/10 (in the other guard’s box in the same room as the mini-boss fight) for the Intensive Treatment wing.

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After having the second child, who is a month old and having a 3 year old, she suffers from anemia and lethargy. What can be done to help improve energy levels? We know about the iron supplements, but were wondering if there was anything else that would help?
no its for the mother not the children
no its for the mother not the children

I would not be asking a question like this for my 3 year old online. It is better to get a doctors opinion that can test your child and see exactly what the child need. There can be so many things. Sometimes a simple chewable multi-vitamin may work, but I would rather get answers that are 100%.

The manufacturers of the erythropoietic agents Procrit, Aranesp and Epogen have provided updated information about certain antibody-mediated reactions in patients treated with these drugs.

Patients taking these drugs can produce antibodies to erythropoietin, resulting in loss of drug activity and pure red cell aplasia or severe anemia. This is most common in patients with chronic renal failure who receive these drugs subcutaneously.

The labeling now says that any patient who suddenly stops responding to Procrit, Aranesp or Epogen and who develops severe anemia and a low reticulocyte count should be evaluated. If you suspect an antibody-mediated anemia, stop using the product and contact the manufacturer to perform antibody assays on the patient’s blood.

If it’s found that the patient has developed antibody-mediated anemia, erythropoietic treatment should be permanently discontinued. These patients should not be switched to other erythropoietic proteins because their antibodies could cross-react with these products as well.

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Of course! So could serum iron, TIBC and ferritin levels.

This is a song I wrote about my feelings about my health problems. Actually the whole story is the following : I felt really low, and I didn’t know how to feel better, so I listened(for like the billionth time) the song A Little Bit Longer (of the Jonas Brothers) and if you know this song and the story of this song you will understand why it inspired me to write my song. So I wrote this song and I already felt better, later on I prayed with some friends of my youth group and now I feel really better. But life keeps being hard. But I know that even if I feel that way about my health and need to take pills everyday(anemia treatment : iron ; low blood pressure treatment ; neurological “disease” treatment to help me managing some disorders ; I have bad digestion so I also have a treatment for this…pills, pills, pills…it’s like a second food for me XD ) I have a friend who helps me to go through everyday and his name is God.
Well, tell me guys what you think

(sorry for the sound and image time-lag…you say that?)
Lyly.

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My daughter is 4 1/2 and we have tried iron rich food, iron supplements, everything PO that we could, we moved on to IV iron but after several treatments she developed an allergy to it. We just recently tried a different form of IV iron but that had no effect on her at all. Now the docs are telling me that the only option we have left is regular blood transfusion which is very risky. I have been told that whenever I take her in to get a transfusion I must realize that I may not be taking her home with me. I am desperate to find out if there is any alternative that anyone knows of. Anything is better than the reality that I am currently faced with, please help and thank you.

This is a very tough question.

Have the doctors try to premedicate him so that he doesn’t develop an allergy? At least in adult medicine, we sometimes premedicate a patient with benadryl and prednisone before giving IV contrast (its a chemical that we inject in people so to obtain a CT scan) if they are allergic to it. So if you premedicate the child, he may not develop the allergy.

What I am curious about is why is he not absorbing or utilizing oral iron supplements? Giving vitamin C with iron supplements sometimes helps with the absorption of iron. Which iron rich foods have you tried? Remember red meats and liver are excellent sources of iron and are easily absorbable. In chinese culture and a few european cultures, cooked blood is eaten.

http://www.burke-eisner.com/practice-areas/benzene-leukemia/aplastic-anemia.html Severe Aplastic anemia can be caused by exposure to Benzene. Benzene is found in many different petroleum products and cleaning agents.

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Please!!!I need help on the guidelines for treating and managing aplastic anemia. Anyone???

Thanks so much!!!

Well aplastic anemia is rather a rare disease, it can be congenital or acquired, most however are idiopathic (without apparent cause). In aplastic anemia, it results on bone marrow aplasia (markedly reduced hematopoiesis). Therefore, in addition to severe anemia, neutropenia and thrombocytopenia (deficiency of platelets) are also seen.

As for the medical management, it is presumed that the lymphocytes of patients with this condition destroy the stem cells and consequently impair the production of RBCs, WBCs and platelets. However, despite this severity, aplsatic anemia can be successfully treated in most people. BMT (Bone marrow transplantation) or PBSCT (Peripheral blood stem cell transplantation) can cure the disease (potentially for younger than 60 years of age, who have compatible donor and otherwise healthy). In some, disease can be managed through immunosuppressive therapy. These immunosuppresants prevents the patient’s lymphocytes from destroy in the stem cells. Antithymocyte globulin and cyclosporine combination is used most commonly. If there is a relapse (patient becomes pancytopenic again), reinstitution of same immunologic agents may induce another transmission. As for the corticosteroids, corticosteroids are not very useful as an immunosuppressive agent because patients with aplastic anemia appear particularly susceptible to the development of bone marrow complications from steroids (example is aseptic necrosis of the head of femur).

Supportive therapy plays a major role in the management of aplastic anemia. Any offending agent is discontinued. Patient is also supported with transfusions of RBCs and platelets as necessary. Death usually is caused by hemorrhage/ infection. Since patients withthis condition are vulnerable to problems associated with RBC, WBC, and platelet deficiencies, they should be assessed carefully for signs of infection and bleeding. Specific interventions also for neutropenia and thrombocytopenia are also used. Sorry for the medical terms. =)